Surgery – Radioactive substance applied to body for therapy – Radioactive substance placed within body
Patent
1997-06-17
1999-11-30
Gilbert, Samuel
Surgery
Radioactive substance applied to body for therapy
Radioactive substance placed within body
A61M 3600
Patent
active
059933747
ABSTRACT:
Disclosed is a site specific microcapsule delivery system and microcapsules for delivering one or more active agents to a preselected site. The system includes a catheter and microcapsules. A preferred embodiment of the catheter includes an inner inflatable balloon having an outer perforated delivery balloon concentrically disposed thereon. The microcapsule preferably comprises a water dissolvable core, and at least one outer protective shell. In a preferred embodiment, the core comprises phosphorous 31 and the outer shell comprises PGLA or other water soluble material. Neutron beam activation of the core produces phosphorous 32, for emitting therapeutic radiation to the treatment site. The outer protective shell dissipates over time, and, following a predetermined delivery period, the outer shell is removed and the central core dissipates to leave only biologically compatible break down products.
REFERENCES:
patent: 2911338 (1959-11-01), Tabern et al.
patent: 3159545 (1964-12-01), Kidwell et al.
patent: 3663685 (1972-05-01), Evans et al.
patent: 3758678 (1973-09-01), Lindsay et al.
patent: 4115536 (1978-09-01), Rothman et al.
patent: 4124705 (1978-11-01), Rothman et al.
patent: 4126669 (1978-11-01), Rothman et al.
patent: 4225790 (1980-09-01), Parsons, Jr. et al.
patent: 4247406 (1981-01-01), Widder et al.
patent: 4349529 (1982-09-01), Morcos et al.
patent: 4409966 (1983-10-01), Lambrecht et al.
patent: 4674480 (1987-06-01), Lemelson
patent: 4706652 (1987-11-01), Horowitz
patent: 4745907 (1988-05-01), Russel, Jr. et al.
patent: 4819618 (1989-04-01), Liprie
patent: 5011677 (1991-04-01), Day et al.
patent: 5019369 (1991-05-01), Presant et al.
patent: 5081110 (1992-01-01), Kim et al.
patent: 5213561 (1993-05-01), Weinstein et al.
patent: 5295962 (1994-03-01), Crocker et al.
patent: 5302168 (1994-04-01), Hess
patent: 5302369 (1994-04-01), Day et al.
patent: 5342283 (1994-08-01), Good
patent: 5411466 (1995-05-01), Hess
patent: 5421826 (1995-06-01), Crocker et al.
patent: 5424288 (1995-06-01), Order
patent: 5498227 (1996-03-01), Mawad
patent: 5503613 (1996-04-01), Weinberger
patent: 5609886 (1998-03-01), Wantier et al.
Microencapsulation and Related Drug Processes, "Solvent Evaporation Process", Patrick B. Deasey, Marcel Dekker, Inc., 1984.
Journal of the American College of Cardiology, "Abstracts of Original Contributions", JACC, vol. 21, No. 2, Feb. 1993.
Local Drug Delivery Catheters: Functional Comparison of Porous and Microporous Designs, Charles R. Lambert, MD, PhD, James E. Leone, AB, BS, and Stephen M. Rowland, PhD, Coronary Artery Disease May 1993, vol. 4 No. 5.
Centrifugal Extrusion Encapsulation, "Encapsulation and Controlled Release of Food Ingredients", Chapter 9, American Chemical Society, Washington, DC 1995.
Local Intramural Drug Delivery Using an Infusion Balloon Following Angioplasty in Normal and Atherosclerotic Vessels, "Catheterization and Cardiovascular Diagnosis", vol. 31, No. 3, Mar. 1994.
A New Approach for Local Intravascular Drug Delivery (Iontophoretic Balloon). Antonio Fernandez-Ortiz, MD, PhD; Beat J. Meyer, MD; Alessandra Mailhac, MD, PhD; Erling Falk, MD; Lina Badimon, PhD; John T. Fallon, MD, PhD; Valentin Fuster, MD, PhD; James H. Chesebro, MD; Juan J. Badimon, PhD, American Heart Association, Circulation vol. 89, No. 4, Apr. 1994.
Low-Dose, .beta.-Particle Emission From `Stent` Wire Results in Complete, Localized Inhibition of Smooth Muscle Cell Proliferation, Tim A. Fischell, MD, Bassam K. Kharma, MD; David R. Fischell, PhD; Peter G. Loges, BS; Circulation, vol. 90, No. 6, Dec. 1994.
Endovascular Low-Dose Irradiation Inhibits Neointima Formation After Coronary Artery Balloon Injury in Swine (A Possible Role for Radiation Therapy in Restenosis Prevention), Ron Waksman, MD; Keith A. Robinson, PhD; Iam R. Crocker, MD; Michael B. Gravanis, MD; Gustavo D. Cipolla, DVM; Spencer B. King III, MD; "American Heart Association", Circulation, vol. 91, No. 5, Mar. 1, 1995.
Regional and Arterial Localization of Radioactive Microparticles After Local Delivery by Unsupported or Supported Porous Balloon Catheters, Robert L. Wilensky, MD, Keith L. March, MD, PhD, Irmina Gradus-Pizlo, MD, Donald Schauwecker, MD, PhD, MaryBeth Michaels, MS, Janine Robinson, MS, Kathy Carlson, and David R. Hathaway, MD, "American Heart Journal" (1995) vol. 129, No. 5, pp. 852-859.
Local Delivery, of Biodegradable Microparticles Containing Colchicine or a Colchicine Analogue: Effects on Restenosis and Implications for Catheter-Based Drug Delivery, Irmina Gradus-Pizlo, MD, Robert L. Wilensky, MD FACC, Keith L. March, MD, PhD, FACC, Naomi Fineberg, PhD, Marybeth Michaels, MS, George E. Sandusky, DVM, PhD David R. Hathaway, MD, FACC, "American College of Cardiology" Nov. 15, 1995, vol. 26, No. 6.
A Survey of Microencapsulation Processes, "Microencapsulation: Methods and Industrial Applications", 1996 by Marcel Dekker, Inc.
Microspheres, Robert L. Wilensky & Keith L. March, Semin Intervent Cardio, 1996; 1: 48-50.
Direct Intraarterial Wall Injection of Microparticles via a Catheter: A Potential Drug Delivery Strategy Following Angioplasty; Robert L. Wilensky, MD, Keith L. March, MD, PhD, and David R. Hathaway, MD, "Progress in Cardiology" American Heart Association, vol. 122, No. 4, Part 1.
Microencapsulation of Multiple Drugs, "Life Sciences" Lyndon B. Johnson Space Center, Houston Texas, NASA Tech Briefs, Nov. 1996.
The Art and Science of Microencapsulation, Southwest Research Institute, San Antonio, Texas, Reprinted from the Jun. 1995 issue of "Technology Today", Brochure.
The Making of Microcapsules, Southwest Research Institute, San Antonio, Texas, Reprint from Sep. 1989 Edition of "Technology Today", Brochure.
Abstracts from the 66th Scientific Sessions, Georgia World Congress Center, Atlanta, Georgia, Nov. 8-11, 1993, American Heart Association, Supplement to Circulation, vol. 88, No. 4, Part 2, Oct. 1993.
The Dose Distribution Produced by a .sup.32 P-coated stent, W.V. Prestwich and T.J. Kennett, F.W. Kus, Medical Physics, vol. 22, No. 3, Mar. 1995.
Abstracts From the 67th Scientific Sessions, Dallas Convention Center, Dallas, TX, Nov. 14-17, 1994, American Heart Association, Circulation, vol. 90, No. 4, Part 2, Oct. 1994.
Pure .beta.-Particle-Emitting Stents Inhibit Neointima Formation in Rabbits, Brief Rapid Communications, Circulation, vol. 93, No. 4, Feb. 15, 1996.
Prophylactic Endovascular Radiotherapy to Prevent Intimal Hyperplasia after Stent Implantation in Femoropopliteal Arteries, Dieter Liermann, Heinz D. Bottcher, Jurgen Kollath, Bernd Schopohl, Gerd Strassmann Ernst-P. Strecker, Karl H. Breddin, CardioVascular and Interventional Radiology, (1994) 17:12-16.
Intracoronary Irradiation Markedly Reduces Restenosis After Balloon Angioplasty in a Porcine Model, Joseph G. Wiedermann, MD, Charles Marboe, MD, Howard Amols, PhD, Allan Schwartz, MD, FACC, Judah Weinberger, MD, PhD, FACC, American College of Cardiology, JACC, vol. 23, No. 6, May 1994: 1491-8.
Gilbert Samuel
Radiance Medical Systems, Inc.
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