Microcapsules containing viable tissue cells

Details Microcapsules containing viable tissue cells Microcapsules containing viable tissue cells

1981-05-01

1983-07-05

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

3 1, 264 4, 424 34, 424 35, 424 94, 435 1, 435175, 435182, 435240, C12N 1110, C12N 1104, C12N 500

Patent

active

043919090

ABSTRACT:
Tissue cells such as islet of Langerhans cells or liver cells are encapsulated within a spheroidal semipermeable membrane comprising a polysaccharide having acidic groups cross-linked with a polymer having a molecular weight greater than 3,000. The cells within the microcapsules are viable, healthy, physiologically active and capable of ongoing metabolism. The encapsulated cells are useful for implantation in a mammalian body to produce substances and effect chemical changes characteristic of the cells in vivo tissue.

REFERENCES:
patent: 3522346 (1970-07-01), Chang
patent: 3725113 (1973-04-01), Chang
patent: 3730841 (1973-05-01), Forgione et al.
patent: 3733205 (1973-05-01), Shovers et al.
patent: 3827565 (1974-08-01), Matsumora
patent: 3860490 (1975-01-01), Guttag
patent: 4138292 (1979-02-01), Chibata et al.
patent: 4251387 (1981-02-01), Lim et al.
Tze et al., Implantable Artificial Endocine Pancreas Unit Used to Restore Normoglyczemia in the Diabetic Rat., Nature, vol. 264, 1976, (pp. 466-467).
Chang, T. M. S., Biomedical Applications of Immobilized Enzymes and Proteins, vol. I, Plenum Press, N.Y., 1977, pp. 69-90 and 147-153).

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