Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1978-12-20
1980-05-27
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
252316, 424 16, 424 19, 424 20, 424 21, 424 22, 424323, 424335, 424 78, 424 81, A61K 950
Patent
active
042050600
ABSTRACT:
Microcapsules comprising a core containing a water-soluble salt of a medicament and a polymer, e.g., the salt of a medicament containing an amine-group and a carboxyl group containing polymer, and a sheath of a water-insoluble film forming polymer, e.g., ethyl cellulose, the method of their production and their administration are disclosed. The microcapsules can be formed by dispersing an aqueous solution of the medicament-polymer salt in a water-immiscible solvent solution of a water-insoluble film forming polymer, adding another water-immiscible solvent which is a non-solvent for the water-insoluble polymer, and collected the microcapsules. The microcapsules are administered orally to animals and exhibit substantially slower release rates and more uniform release rates in stomach acids than the corresponding unencapsulated salts or encapsulated non-polymeric salts.
REFERENCES:
patent: 3608063 (1971-09-01), Banker
patent: 3629392 (1971-12-01), Banker et al.
patent: 3909444 (1975-09-01), Anderson et al.
patent: 4016254 (1977-04-01), Seager
Bohm Howard A.
Monsimer Harold G.
Pennwalt Corporation
Rose Shep K.
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