Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1994-01-10
1995-07-18
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
42840221, 4284022, 264 41, 264 433, 264 47, A61K 950, A61K 3114
Patent
active
054339537
ABSTRACT:
A method for microencapsulating quaternary ammonium salts by interfacial polymerization. The polar component comprises a quaternary ammonium salt, glycerine, triethyleneglycol diamine, a C 4-10 straight or branched aliphatic compound having two primary amine functionalities, and a C 4-10 straight or branched aliphatic compound having at least three primary amine functionalities. The glycerine-immiscible oil component comprises mineral oil, an aliphatic polyisocyanate and a surfactant. The mole equivalent ratios of primary amine to isocyanate in this reaction is about 0.01-3:1. Microcapsules made by this method are unique and provide surprising benefits in durability, elasticity and barrier properties in resistance to leaching of the microcapsule fill material.
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Mitra Smarajit
Tsuei Alexander C.
Bjorkman Dale A.
Griswold Gary L.
Kirn Walt N.
Minnesota Mining and Manufacturing
Page Thurman K.
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