Microcapsule containing amorphous water-soluble 2-piperazinone-1

Details Microcapsule containing amorphous water-soluble 2-piperazinone-1 Microcapsule containing amorphous water-soluble 2-piperazinone-1

1996-09-30

1999-03-02

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424426, 514821, 514822, 514951, 514963, 514964, 264 46, A61K 952

Patent

active

058767568

ABSTRACT:
A microcapsule contains a pharmaceutically effective amorphous water-soluble 2-piperazinone-1-acetic acid compound or salt thereof and a polymer binder and a method of preparing said microcapsule. The microcapsule is produced by dispersing in an aqueous phase a dispersion of the amorphous water-soluble 2-piperazinone-1-acetic acid compound or salt thereof in a solution of a polymer in an organic solvent to give an s/o/w type emulsion and subjecting the emulsion to in-water drying. The sustained-release microcapsule entraps 2-piperazinone-1-acetic acid compound or the salt thereof, as a drug, in high concentration, and in reducing the initial release of the drug, thereby reducing undesirable side effects of the drug.

REFERENCES:
patent: 4954298 (1990-09-01), Yamamoto et al.
patent: 5330767 (1994-07-01), Yamamoto et al.
patent: 5622657 (1997-04-01), Takada et al.
J. Pharm. Sciences, vol. 75, No. 8 (1986) 750-755.

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