Microcapsule composition suitable for cardiovascular injection

Details Microcapsule composition suitable for cardiovascular injection Microcapsule composition suitable for cardiovascular injection

1984-07-16

1988-12-06

Rosen, Sam

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424491, 424497, 435 1, 435178, 435182, 435180, 43524022, A61K 922, A61K 924

Patent

active

047895500

ABSTRACT:
Perfectly spherical, smooth and uniform microcapsules, which may contain living cells, are produced having a diameter less than 700 .mu.m, e.g. 150 to about 500 microns, by employing an electrostatic droplet generator. A droplet is suspended from a pointed source, such as a needle, and is charged with high static voltage. A collecting vessel or ring device is charged with opposing polarity and attracts the droplet When a voltage potential threshold is passed, the droplet moves from the source to the collecting vessel. The voltage pulse height, pulse frequency and length, and extrusion rate of the droplet are adjustable so that predetermined sizes of droplets may be repeatedly generated and collected.

REFERENCES:
patent: 4391909 (1983-07-01), Lim
patent: 4407957 (1983-10-01), Lim
patent: 4409331 (1983-10-01), Lim
patent: 4543332 (1985-09-01), Jao et al.
patent: 4673566 (1987-06-01), Goosen et al.
patent: 4689293 (1987-08-01), Goosen et al.

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