Microbubble precursors and methods for their production and use

Details Microbubble precursors and methods for their production and use Microbubble precursors and methods for their production and use

1981-11-17

1984-04-17

Howell, Kyle L.

Surgery

Truss

Pad

128661, 128663, 128653, A61G 1000

Patent

active

044428430

ABSTRACT:
Microbubbles are formed in a liquid, e.g., blood in order to alter the transmission characteristics thereof to electromagnetic and sonic waves transmitted therethrough, by dissolving therein a solid particulate material, preferably as a suspension in a carrier liquid in which the particulate material is at least temporarily stable, the particles of which are substantially free of microbubbles and have a plurality of gas-filled voids communicating with the surface of the particles and providing nuclei for microbubble formation and the ratio of the mass of the particles to the volume of gas in the voids is sufficient to render the liquid in which the particulate material is dissolved supersaturated with respect to the gas in the voids in the area of the liquid surrounding the microbubbles when they are formed.

REFERENCES:
patent: 4265251 (1981-05-01), Tickner
patent: 4276885 (1981-07-01), Tickner et al.
Meltzer et al., "The Source of Ultrasound Contrast Effect", Journal of Clinical Ultrasound, pp. 121-127, Apr. 1980.

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