Microbubble compositions and methods for oligonucleotide...

Details Microbubble compositions and methods for oligonucleotide... Microbubble compositions and methods for oligonucleotide...

2006-10-03

2006-10-03

Zara, Jane (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C424S009520, C435S006120, C435S091100, C514S001000, C514S002600, C530S350000, C530S362000, C530S363000, C530S380000, C536S023100, C536S024500

Reexamination Certificate

active

07115583

ABSTRACT:
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.

REFERENCES:
Peracchi, A. et al., rev. Med. Virol., vol. 14, pp. 47-64 (2004).
Agrawal, S. et al., Molecular Med. Today, vol. 6, pp. 72-81 (2000).
Chirila, T. et al., Biomaterials, vol. 23, pp. 321-342 (2002).
Branch, A., Trends in Biochem. Sci. (TIBS), vol. 23, pp. 45-50 (1998).
Crooke, S., Antisense Research & Application, Chapters 1 and 2, pp. 1-50, Ed. S. Crooke, Published by Springer-Verlag (1998).

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