Microbiological process for the production of malonyl-7-amino-ce

Details Microbiological process for the production of malonyl-7-amino-ce Microbiological process for the production of malonyl-7-amino-ce

1993-04-27

1994-08-16

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

435 41, 435 49, 435822, 4352521, C12P 100, C12P 3500, C12P 3506, C12N 100

Patent

active

053386671

ABSTRACT:
Disclosed is a microbiological process which utilizes a biologically pure culture of Sphingomonas sp. DSM 7007 in order to produce a malonyl-7-aminocephalosporanic acid derivative product. Furthermore the process uses cephalosporin C derivative as a substrate for the conversion of the cephalosporin C into the product. The process takes place by one time or continuous addition of substrate so that the concentration of cephalosporin C does not exceed 20 percent by weight. Furthermore, the process is performed at a temperature range of 0-60 degrees celsius and a pH range of 5 to 9.

REFERENCES:
J. Bacteriol., vol. 169, No. 12, (1987), pp. 5815 to 5820.
Jeffery et al., Biochem. J., 81, (1961), pp. 591 to 596.
Bull. Soc. Chem. Belg., 86, (1977), pp. 991 to 1002.

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