Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1995-02-03
1996-05-14
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
4352521, 4352533, 435822, 435829, 435874, C12P 1712, C12N 120
Patent
active
055166610
ABSTRACT:
The microbiological process for the production of hydroxy-heterocyclic carboxylic acid of formula ##STR1## wherein R.sub.1 means a hydrogen or a halogen atom and X means a nitrogen atom or a CR.sub.2 function, wherein R.sub.2 means a hydrogen or halogen atom, starting from the corresponding heterocyclic carboxylic acid. The process is performed so that an aerobic biomass which utilizes nicotinic acid, is cultivated in a molar ratio of nicotinic acid to mineral acid of 1 to 8. The ratio is assured over the entire cultivation phase. The the hydroxylation of the corresponding heterocyclic carboxylic acid of the general formula ##STR2## wherein R.sub.1 and X have the above-mentioned meanings, is performed with the biomass. Under these conditions, strain Pseudomonas acidovorans DSM 7205, strain Pseudomonas acidovorans DSM 7203, strain Alcaligenes faecalis DSM 7204 and strain Arthrobacter crystallopoietes DSM 7202 are concentrated in the cultivation phase.
REFERENCES:
patent: 4738924 (1988-04-01), Kulla et al.
patent: 5151351 (1992-09-01), Hoeks
patent: 5273893 (1993-12-01), Kiener
Weiner et al., Journal of Pharmacology and Experimental Therapeutics, 180(2):411-434, (1972).
ATCC Catalogue of Bacteria & Bacteriophages, 18th Ed., (1992), p. 22.
Chemical Abstracts, Ensign, C., et al., vol. 61, No. 2, (Jul. 20, 1964), No. 2208f.
Database WPI, AN92-409786, abstract of Japanese Published Patent Application No. 4304893 (Oct. 28, 1993).
Chemical Abstracts, Nagasawa, I., (Mar. 28, 1994), No. 120:161783u.
Chemical Abstracts, Hughs, D. E., vol. 47, No. (Mar. 25, 1953), No. 2832h.
Chemical Abstracts, Foks, H. et al., vol. 66, No. 21, (May 22, 1967), No. 94996s.
Chemical Abstracts, Yamamoto, T. et al., vol. 107, No. 25, (Dec. 21, 1987), No. 228395w.
Setcliff et al., J. of Chem. and Eng. Data, (1976), vol. 21, No. 2, p. 246.
Heinzmann Klaus
Kiener Andreas
Rohner Markus
Lilling Herbert J.
Lonza Ltd.
LandOfFree
Microbiological process for the production of aromatic hydroxy-h does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microbiological process for the production of aromatic hydroxy-h, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microbiological process for the production of aromatic hydroxy-h will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1895012