Microbiological process for the preparation of heteroaromatic ca

Details Microbiological process for the preparation of heteroaromatic ca Microbiological process for the preparation of heteroaromatic ca

1996-06-06

1997-12-30

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435170, 4352521, C12P 1712, C12P 104, C12P 120

Patent

active

057029300

ABSTRACT:
A microbiological process for the preparation of a heteroaromatic carboxylic acid or one of its physiologically tolerated salts of the formulae I or II: ##STR1## wherein R.sub.1 and R.sub.2 are identical or different and each denotes a hydrogen or halogen atom, and X denotes a nitrogen atom or CH--, from a heteroaromatic nitrile of the formulae III or IV, respectively: ##STR2## First, a microorganism, Alcaligenes faecalis (DSM 6335), is cultured in the presence of an inducer, 2-cyanopyridine, and a carbon source such as a dicarboxylic acid, a tricarboxylic acid or a carbohydrate. Substrate III or IV is then reacted with the cultured microorganism. The biotransformation is carried out under anaerobic conditions for compounds of the formula I, and under aerobic conditions for compounds of the formula II.

REFERENCES:
patent: 5264361 (1993-11-01), Kiener
patent: 5270203 (1993-12-01), Kiener
Fischer et al. Berichte der Deutschen Chemischen Gesellschaft (1912) 45: 2456-2467.
Krieg, N. and Holt, J., Eds. Bergey's Manual of Systematic Bacteriology. vol. 1. Williams and Watkins: Baltimore. pp. 361-373, 1984.
Kobayashi et al., J. of Antibiotics, vol. 43, No. 10, (1990), pp. 1316-1320.
Mathew et al., Appln. Environmental Microbiology, vol. 54, No. 4 (1988) pp. 1030-1032.

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