Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1987-04-09
1990-07-31
Warren, Charles F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 4352523, 43525233, 4351721, 435 698, 935 41, 935 56, 935 60, 935 73, 935 61, C12P 2100, C12N 1500, C12R 107, C12R 1185
Patent
active
049450476
ABSTRACT:
The invention relates to a microbiological process for the preparation of a protein by culturing a mutant bacterial strain.
This process consists in using a bacterial strain carrying a mutation which limits, or even suppresses, the expression of the operons whose transcription depends on the fixation of the cAMP-CRP complex, a DNA sequence coding for a protein precursor having been introduced into the said bacterial strain.
REFERENCES:
Dunlap et al., 1985, J. Bacteriol., 164(1):45-50.
Amann et al., 1983, Gene, 25:167-178.
J. Daniel; Fems Microbiology Letters, vol. 24, 1984, pp. 215-218.
G. L. Gray et al.; Gene, vol. 39, No. 2/3, 1985, pp. 247-254.
R. Utsumi; Agricultural and Biological Chemistry, vol. 48, No. 8, 1984, pp. 2129-2130.
A. H. Koop et al.; Gene, vol. 28, 1984, pp. 133-146.
Joseph Evelyne L.
Legoux Richard
Leplatois Pascal
Niaudet Brigitte
Roskam Willem
Fox David T.
Societe Anonyme: Sanofi
Warren Charles F.
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