Microbiological process for preparing 9.alpha.-hydroxy-4-androst

Details Microbiological process for preparing 9.alpha.-hydroxy-4-androst Microbiological process for preparing 9.alpha.-hydroxy-4-androst

1987-11-05

1991-04-02

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 55, 435863, 435 56, C12N 120, C12P 3316, C12P 3318

Patent

active

050046950

ABSTRACT:
The invention relates to a process for the production of 9.alpha.-hydroxy-4-androstene-3,17-dione from natural sterols of plant or animal origin or from mixtures thereof by the submerged aerobic fermentation of an enzyme-deficient, sterol-de-grading microorganism in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product formed, which comprises transforming the sterol or sterol mixture with the culture of a 1,2-steroid-dehydrogenase deficient strain of new Mycobacterium roseum species which is able to degrade the side-chain of natural sterols, preferably with Mycobacterium roseum sp. nov. 1108/1 deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM B (P) 000339, and by isolating and purifying the 9.alpha.-hydroxy-4-androstene-3,17-dione obtained.

REFERENCES:
patent: 4035236 (1977-07-01), Wovcha

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