Microbiological process for hydroxylation of nitrogen-heterocycl

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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546290, 546298, 435122, C07D24102, C07D21172, C07D21184

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053649400

ABSTRACT:
A new microbiological process for the production of hydroxy-nitrogen-heterocyclic-carboxylic acids or their soluble salts of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.4 alkyl group and X is a nitrogen atom or a CR.sub.3 function, wherein R.sub.3 is a hydrogen atom or a halogen atom, starting from the corresponding nitrogen-heterocyclic-carboxylic acids, as well as new microorganisms suitable for use in the process.

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Bobek (1991) J. Heterocyclic Chem., 28, 1131-1137.
Gage et al. (1981), J. Heterocyclic Chem., 19, 401-406.
Weiner et al. (1971), J. Pharmacology and Experimental Therapeutics, 180, 411-434 (1972).
Chemical Abstracts, 94:15515m, (1981).

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