Microbiological modification of antibiotic A23187 esters

Details Microbiological modification of antibiotic A23187 esters Microbiological modification of antibiotic A23187 esters

1978-12-20

1981-01-27

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435119, 435893, C07D49310

Patent

active

042477034

ABSTRACT:
Cultivation of Streptomyces chartreusis NRRL 11407 in the presence of antibiotic A23187 methyl ester produces 16-hydroxy A23187 methyl ester, 16-hydroxy-N-demethyl A23187 methyl ester, and N-demethyl A23187 methyl ester. Hydrolysis of the products affords the corresponding free acids which form dimeric complexes with divalent cations.

REFERENCES:
patent: 3923823 (1975-12-01), Gale et al.
patent: 3960667 (1976-06-01), Gale et al.
Kondorosi, Chem. Abs. 88, 16, 6181c, (1977).

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