Microbiological methylation of aminoglycosyl-aminoglycosides

Details Microbiological methylation of aminoglycosyl-aminoglycosides Microbiological methylation of aminoglycosyl-aminoglycosides

1980-06-12

1982-09-07

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 435 80, 536 17R, A61K 3171, C07H 1522

Patent

active

043485162

ABSTRACT:
The microorganisms Micromonospora inyoensis 1550F-1G and M. purpurea strain 1124 each microbiologically convert tobramycin, kanamycin A, kanamycin B and dibekacin to their respective 3"-N-methyl and 3"-N-methyl-4"-C-methyl derivatives. The derivatives exhibit significant activity against representative gram positive and gram negative bacteria and may also be converted to other derivatives which have significant antibacterial activity.

REFERENCES:
patent: 4044123 (1977-08-01), Daniels et al.
patent: 4051315 (1977-09-01), Godfrey et al.
patent: 4066752 (1978-01-01), Mallams et al.

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