Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1979-06-25
1980-11-18
Shapiro, Lionel M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435862, 435867, 536 10, C12P 1948
Patent
active
042346851
ABSTRACT:
The microorganisms Micromonospora inyoensis 1550F-1G and M. purpurea strain 1124 each microbiologically convert tobramycin, kanamycin A, kanamycin B and dibekacin to their respective 3"-N-methyl and 3"-N-methyl-4"-C-methyl derivatives. The derivatives exhibit significant activity against representative gram positive and gram negative bacteria and may also be converted to other derivatives which have significant antibacterial activity.
REFERENCES:
patent: 2931798 (1960-04-01), Umezawa et al.
patent: 4011390 (1977-03-01), Weinstein et al.
Daniels Peter J. L.
Lee Bong K.
Marquez Joseph A.
Rane Dinanath F.
Wagman Gerald H.
Joyner Carver C.
Schering Corporation
Shapiro Lionel M.
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