Microbiological methods using hollow fiber membrane reactor

Details Microbiological methods using hollow fiber membrane reactor Microbiological methods using hollow fiber membrane reactor

1983-06-20

1984-04-03

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435 41, 435174, 435182, 435284, 435287, 435813, C12P 100, C12P 2100, C12N 1100

Patent

active

044408536

ABSTRACT:
Methods for microbiological processing of organic materials for production of valuable products. Asymmetric hollow fibers are employed in a flow reactor, where the hollow fibers have a semipermeable membrane surrounding a lumen, where the semipermeable membrane is supported by a sponge structure. The pores of the sponge structure serve as a housing for microorganisms or cells with high density packing of the microorganisms or cells in the pores. Nutrient medium continuously flowing through the lumen provides nutrients to the microorganisms or cells as well as any substrates to be processed by the microorganisms or cells. The nutrients and substrates diffuse through the semipermeable membrane into the pores, where they are processed, and the metabolic products diffuse into the lumen. The lumen effluent is then processed for the desired products. Optionally, oxygen is provided external to the hollow fiber to enhance the amount of oxygen available to the microorganisms and cells.

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Kan et al., "Urocanic Acid Production Using Whole Cells Immobilized on a Hollow-Fiber Reactor", Biotechnology and Bioengineering, vol. XX, (1978), pp. 271-320.
Webster et al., Biotechnology and Bioengineering, vol. XX, (1979), pp. 1725-1748, Abstract only.
Webster et al., Biotechnology and Bioengineering, vol. XX, (1978), pp. 1273-1282, Abstract only.
Webster et al., Chemical Engineering Science, vol. 34, (1979), pp. 1273-1282.

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