Microbiological conversion of sterol derivatives to 5-androsten-

Details Microbiological conversion of sterol derivatives to 5-androsten- Microbiological conversion of sterol derivatives to 5-androsten-

1976-07-30

1979-10-09

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a...

C07B 2902

Patent

active

041705181

ABSTRACT:
Sterol derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom and R.sub.2 is lower alkoxy, or R.sub.1 and R.sub.2 collectively are lower alkylenedioxy and R.sub.3 is a sterol hydrocarbon side chain are converted to the corresponding androsten-17-ones by the oxidative degradation activity of a species of microorganism which degrades sterol side chains, preferably of the genus Mycobacterium. The ether group of those compounds wherein R.sub.1 is a hydrogen atom and R.sub.2 is lower alkoxy, and the corresponding 17.beta.-hydroxy and 17.alpha.-hydrocarbon-17.beta.-hydroxy compounds is cleaved by reaction with an alkanoic acid chloride or anhydride in the presence of a Lewis acid.

REFERENCES:
patent: 3759791 (1973-09-01), Marsheck et al.
Buki et al, Acta Microbiol. Acad. Sci. Hung. 22, 447-451, (1975).

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