Microbiological assay of aminoglycoside antibiotics

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1951035R, 1951035K, C12K 100

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040736946

ABSTRACT:
A method of measuring the level of an aminoglycoside antibiotic, such as gentamicin, tobramycin or amikacin, in blood serum or plasma comprising incubating an aliquot of blood serum or plasma from a human patient being treated with an aminoglycoside antibiotic in a urea-containing culture medium with a susceptible strain of an adaptive urease producing microorganism corresponding to Proteus rettgeri JLI 03, ATCC No. 31168.

REFERENCES:
noone et al., Simple, Rapid Method for Assay of Aminoglycoside Antibiotics, Lancet, Jul. 3, 1971, pp. 16-19.
Ibid, Dec. 2, 1972, pp. 1194-1195.

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