Microbially-stable bismuth-containing liquid pharmaceutical susp

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof

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Details

514503, 514867, 514872, A01N 5916, A01N 5502, A61K 3324, A61K 3129

Patent

active

050135600

ABSTRACT:
Microbially-stable liquid pharmaceutical suspensions for oral administration comprising a bismuth-containing pharmaceutical agent, benzoic acid, sorbic acid, a suspension system and water, and wherein said compositions have a pH within the range of from about 3.0 to about 5.5. These compositions are efficacious, and have good aesthetics and good storage stability.

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Antimicrobials in Foods, Chapter 2 (Chipley, J. R.), pp. 11-35 (1983).
Antimicrobials in Foods, Chapter 6 (Sofos et al.), pp. 141-175 (1983).
Beuchat, "Synergistic Effects of Potassium Sorbate and Sodium Benzoate on Thermal Inactivation of Yeasts", Journal of Food Science, vol. 46, pp. 771-777 (1981).
Beuchat, "Influence of Potassium Sorbate and Sodium Benzoate on Heat Inactivation of Aspergillus flavus, Penicillium puberulum and Geotrichum candidum", Journal of Food Protection, vol. 44(6), pp. 450-454 (Jun. 1981).
Rushing and Senn, Proc. Fla. State Hortic. Soc., vol. 76, p. 271 (1963).

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