Microbial transformation process for producing antihypertensive

Details Microbial transformation process for producing antihypertensive Microbial transformation process for producing antihypertensive

1992-05-18

1993-06-08

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 84, 435119, 435886, C12P 1928, C12P 1926, C12R 1465

Patent

active

052178820

ABSTRACT:
Fermentation of the microorganism Streptomyces sp. MA6751 (ATCC No. 55043) in the presence of the Angiotensin II (A II) receptor antagonist ##STR1## yields an N2-glucuronide analog which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.

REFERENCES:
patent: 5066586 (1991-11-01), Chen
patent: 5085992 (1992-02-01), Chen et al.
patent: 5128355 (1992-07-01), Carini et al.
patent: 5132216 (1992-07-01), Chen et al.
patent: 5138069 (1992-08-01), Carini et al.
patent: 5153197 (1992-10-01), Carini et al.
Ralph A. Stearns et al., Drug Metabolism and Disposition, vol. 20, No. 2, pp. 281-287 (1992).

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