Microbial transformation process for producing an antihypertensi

Details Microbial transformation process for producing an antihypertensi Microbial transformation process for producing an antihypertensi

1991-01-30

1992-02-11

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435119, C07D47104, C12P 1718

Patent

active

050877020

ABSTRACT:
Fermentation of the microorganism Streptomyces sp. (MA6750) ATCC No. 55042 in the presence of the Angiotensin II (A II) receptor antagonist of the following structure: ##STR1## yields an analog having a shikimate sugar-like moiety attached to the tetrazole, the said analog which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II angatonists.

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