Microbial transformation of taxol and cephalomannine

Details Microbial transformation of taxol and cephalomannine Microbial transformation of taxol and cephalomannine

1996-10-17

1998-05-26

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549510, 549511, A61K 31335, C07D30514

Patent

active

057565368

ABSTRACT:
A biotransformation process for the production of hydroxylated derivatives of taxol and new derivatives of taxol and cephalomannine are described. A method for converting taxol to L-760,006 and L-760,007, and a method for converting cephalomanine to L-745,596 are provided.

REFERENCES:
patent: 5322779 (1994-06-01), Strobel et al.
patent: 5407674 (1995-04-01), Gabetta et al.
Kingston, "The Chemistry of Taxol", Pharmac. Ther., vol. 52, pp. 1-34, 1991 .

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