Microbial transformation of a substituted pyridinone using strep

Details Microbial transformation of a substituted pyridinone using strep Microbial transformation of a substituted pyridinone using strep

1991-06-07

1993-06-01

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

4352535, 435121, C12P 1714

Patent

active

052159000

ABSTRACT:
Fermentation of the microorganism Streptomyces sp. (MA6804), ATTC No. 55095, in the presence of the HIV reverse transcriptase inhibitor ##STR1## yields a 5-(1-hydroxy)ethyl analog which is useful in the prevention or treatment of infection by HIV and the treatment of AIDS.

REFERENCES:
patent: 3715358 (1973-02-01), Witzel et al.
patent: 3835143 (1974-09-01), Witzel et al.
patent: 3846553 (1974-11-01), Shen et al.

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