Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing nitrogen-containing organic compound
Reexamination Certificate
2006-07-27
2009-06-30
Lilling, Herbert J. (Department: 1657)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing nitrogen-containing organic compound
C514S618000, C514S630000, C564S154000, C564S162000
Reexamination Certificate
active
07553646
ABSTRACT:
The present invention provides novel methods for the synthesis of racemic and enantiomers of modafinil via microbial oxidation-amidation transformation. The methods include the successive oxidation-amidation of benzhydrylsulfanyl carboxylic acid to produce racemic and enantiomers of modafinil using at least one microorganism of yeast, bacteria, or fungus. Also disclosed are pharmaceutical compositions of racemic and enantiomers of modafinil along with their use in the treatment of diseases, including attention deficit hyperactivity disorder and drug addiction.
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Osorio-Lozada et al., “Synthesis and determination of the absolute stereochemistry of the enantiomers of adrafinil and modafinil”, Tetrahedron: Asymmetry, 15:3811-3815 (2004).
Prisinzano, Thomas et al., “Synthesis and determination of the absolute configuration of the enantiomers of modafinil”, Tetrahedron: Asymmetry, 15:1053-1058 (2004).
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Olivo Horacio F.
Osorio-Lozada Antonio Victor
Lilling Herbert J.
McKee Voorhees & Sease, P.L.C.
University of Iowa Research Foundation
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