Microbial production of mature human leukocyte interferon K and

Details Microbial production of mature human leukocyte interferon K and Microbial production of mature human leukocyte interferon K and

1987-06-01

1989-01-31

Hazel, Blondel

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

424 857, 435 68, 435811, C07K 1300, C07K 1526, A61K 4502, C12P 2100

Patent

active

048016853

ABSTRACT:
This invention relates to the microbial production, via recombinant DNA technology, of new human leukocyte interferons, Le IF-K and Le IF-L for use in the treatment of viral and neoplastic diseases, and to the means and end products of such production.

REFERENCES:
patent: 4289690 (1981-09-01), Pestka et al.
patent: 4342832 (1982-08-01), Goeddel et al.
Nagata et al., Nature, vol. 284, pp. 316-320, 1980.
Goeddel et al., Nature, vol. 290, pp. 20-26, 1981.
Torma and Paucher, J. Biol. Chem., vol. 254, pp. 4810-4816, 1976.
Taniguchi et al., Nature, vol. 285, pp. 547-549, 1980.
Rubinstein et al., Proc. Natl. Acad. Sci., vol. 76, pp. 640-644, 1979.
Manter et al., Gene, vol. 10, pp. 1-10, 1980.
Goeddel et al., Nature, 281:544-548 (10/18/79).
Lawn et al. DNA Sequence of Two Closely Linked Human Leukocyte Interferon Genes, Science, vol. 212, Jun. 5, 1981, p. 1159.
Yelverton et al., Nucleic Acid Research, vol. 9, No. 3, 1981, p. 73).

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