Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1996-12-11
1999-02-02
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
536 232, C12N 914, C07H 2104
Patent
active
058663967
ABSTRACT:
There is provided an improved process for the biosynthetic production of indigo, the improvement comprising removing unwanted by-products such as isatin or indirubin from the broth in which such indigo is produced. Isatin can be removed by enzymatic activity using an isatin-removing enzyme such as an isatin hydrolase, or by other techniques such as process parameters (elevated temperature, pH), or by contacting the broth containing the isatin with appropriate adsorption compounds/compositions such as carbon or appropriate resins. Since isatin is the precursor of indirubin, the indirubin levels are decreased as a result of isatin removal.
REFERENCES:
Olesen et al. (1996) Identification of the enzymes involved in indole-3-acetic acid degradation, Plant Soil 186 (1): 143-149. (CAPLUS Accession Number 1997:68489; Document No. 126:141254, Jan. 1996.
Dodge Timothy C.
Lauff John J.
Wendt Dan J.
Weyler Walter
Anderson Kirsten A.
Stole Einar
Wax Robert A.
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