Microbial production of COQ10

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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C435S194000, C435S320100, C435S252300, C536S023200

Reexamination Certificate

active

07435571

ABSTRACT:
The present Invention relates to enzymes involved in the Synthesis of Coenzyme Q-10, i.e., decaprenyl diphosphate (DPP) synthase and 4-hydroxybenzoate polyprenyltransferase, to isolated DNA encoding said enzymes and to methods for the microbial production of Coenzyme Q-10.

REFERENCES:
patent: 3891504 (1975-06-01), Schocher et al.
patent: 1 227 155 (2002-07-01), None
Humbelin M. et al., Genetic of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens, Gene, 2000, 297, 129-139.
Hümbelin et al., “Decaprenyl Diphosphate Synthase(EC 2.1.1.31),” EBI Database Accession No. Q8L116.
Hümbelin et al., “Genetics Of Isoprenoid Biosynthesis In Paracoccus Zeaxanthinifaciens,”Gene, vol. 297, pp. 129-139 (2002).
Huembelin et al., “Paracoccus Zeaxanthinifaciens phaA gene, phaB gene, ORFI and ddsA Gene,” EBI Database Accession No. AJ431695, XP002281316.

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