Microbial production of certain isoflavones

Details Microbial production of certain isoflavones Microbial production of certain isoflavones

1974-07-23

1976-08-10

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603455, 195 80R, C07D31136

Patent

active

039741842

ABSTRACT:
This invention relates to the novel compounds 3',5,7-trihydroxy-4',6-dimethoxy-isoflavone, 3'5,7-trihydroxy-4',8-dimethoxy-isoflavone and 3',7-dihydroxy-4',6,8-trimethoxy-isoflavone which are powerful inhibitors of catechol-O-methyl transferase (COMT) and to their production by fermentation of Actinomyces roseolus.

REFERENCES:
patent: 2350804 (1944-06-01), Ohta
patent: 2764596 (1956-09-01), Avakian
patent: 3352754 (1967-11-01), Gazave
patent: 3598840 (1971-08-01), Majoie
patent: 3661890 (1972-05-01), Jurd
patent: 3704323 (1972-11-01), Krapcho
Morita et al. Yakugaku Zasshi, 92, 1052 (1972).
Kawase et al., Agr. Biol. Chem., 37, 145 (1973).
Prakash et al., J. Org. Chem., 30, 3561 (1965).

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