Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide
Patent
1989-12-20
1992-10-20
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using a micro-organism to make a protein or polypeptide
435 713, 435254, 435911, 514 11, 530317, 530321, C12P 2104, C12R 1645, A61K 3700
Patent
active
051569604
ABSTRACT:
The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25.degree. to 30.degree. C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.
REFERENCES:
patent: 4215199 (1980-07-01), Harri et al.
patent: 4288431 (1981-09-01), Traber et al.
patent: 4289851 (1981-09-01), Traber et al.
patent: 4764503 (1988-08-01), Wenger
Albrecht Karoly
Ambrus Gabor
Andor Attila
Buzasi Karoly
Deli nee Konszky Etelka
Biogal Gyogyszergyar
Lilling Herbert J.
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