Microbial process for the preparation of milbemycin derivatives

Details Microbial process for the preparation of milbemycin derivatives Microbial process for the preparation of milbemycin derivatives

1990-03-20

1993-02-02

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435 58, 435886, 435917, 435822, 435911, 435254, 4352535, C12P 1718, C12P 3306, C12N 114, C12N 120

Patent

active

051837498

ABSTRACT:
The present invention relates to a one-step microbial process for the preparation of 13.beta.-hydroxy- or 14,15-epoxy-milbemycins of the following formulae I and II ##STR1## in which R.sub.1 and R.sub.1 ' represent methyl, ethyl, isopropyl or sec.-butyl or represent the group ##STR2## in which X represents methyl, ethyl or isopropyl, and A and A' represent the group ##STR3## in which R.sub.2 represents hydrogen, --C(O)-CH.sub.2 O-C(O)-CH.sub.2 CH.sub.2 -COOH or --C(O)-CH.sub.2 CH.sub.2 -COOH, or mixtures of compounds of the formulae I and II, which process comprises bringing a milbemycin of the formula III ##STR4## dissolved in a liquid phase, in which R.sub.3 represents R.sub.1 or R.sub.1 ' and R.sub.4 represents A or A', and R.sub.1, R.sub.1 ', A and A' have the meanings given for formulae I and II, into contact with a microorganism that is capable of 13.beta.-hydroxylation or 14,15-epoxidation or of both reactions, or into contact with active constituents thereof. The microorganism or its active constituents may be either in free form or immobilized form.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 4173571 (1979-11-01), Chabala et al.
patent: 4226941 (1980-10-01), Goi et al.
patent: 4328335 (1982-05-01), Mrozik
patent: 4346171 (1982-08-01), Takiguchi et al.
patent: 4547520 (1985-10-01), Ide et al.
patent: 4666937 (1987-05-01), Goegelman
patent: 4696922 (1987-09-01), Sturm et al.
patent: 4696945 (1987-09-01), Frei et al.
ATCC Catalogue of Fungi, 1987, pp. 44-46.
Enzymes: Chapter 9: Mechanism, structure, and regulation, ed. Albert L. Lehninger, Worth Publishers, Inc., 1975, pp. 217, 218.

Affiliated with

Also associated with

Rating

Microbial process for the preparation of milbemycin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microbial process for the preparation of milbemycin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microbial process for the preparation of milbemycin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-6520