Microbial process for producing 12.alpha.-hydroxypregna-1,4-dien

Details Microbial process for producing 12.alpha.-hydroxypregna-1,4-dien Microbial process for producing 12.alpha.-hydroxypregna-1,4-dien

1982-10-15

1985-05-28

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a...

4351721, 435874, 435829, C12P 3302, C12N 1500, C12R 105, C12R 138

Patent

active

045201021

ABSTRACT:
A microbial process for producing 12.alpha.-hydroxypregna-1,4-dien-3-one-20.alpha.-carboxylic acid or a salt thereof which comprises cultivating a microbe of the species Pseudomonas arvilla or the genus Alcaligenes, e.g. Alcaligenes faecalis, which is capable of producing 12.alpha.-hydroxypregna-1,4-dien-3-one-20.alpha.-carboxylic acid or a salt thereof by utilizing deoxycholic acid or a salt thereof as a substrate, in a culture medium containing the substrate and collecting the resulting compound.

REFERENCES:
patent: 3022226 (1962-02-01), Ross et al.
Barnes et al., Tetrahedron, vol. 32, pp. 89-93, 1976.

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