Microbial process for preparation of indolopyrrolocarbazole deri

Details Microbial process for preparation of indolopyrrolocarbazole deri Microbial process for preparation of indolopyrrolocarbazole deri

Filed on

1995-06-07

Date issued

1997-07-01

Examiner

Marx, Irene

Patent Class

Chemistry: molecular biology and microbiology

SubClass

Micro-organism, tissue cell culture or enzyme using process...

SubSubClass

Preparing compound containing saccharide radical

Other Related Categories

435121, 435119, 4352521, C12P 1928, C12N 120

Type

Patent

Status

active

Patent number

056437609

Description

ABSTRACT:
Indolopyrrolocarbazole derivatives, such as, for example, 12,13-dihydro-1,11-dihydroxy-13-(.beta.-D-glucopyranosyl)-5H-indolo[2,3-a] pyrrolo[3,4-c]carbazole-5,7-(6H)-dione or 6-amino derivative thereof, are produced by glycosylating a precursor compound by cultivating with Microtetraspora sp. A34549, Saccharothrix aerocolonigenes ATCC 39243 or mutants thereof, in a nutrient medium containing the precursor compound.

REFERENCES:
patent: 4552842 (1985-11-01), Nettleton
patent: 4567143 (1986-01-01), Matson
patent: 5015578 (1991-05-01), Schroeder
patent: 5192671 (1993-03-01), Arison
Patent Abstract of Japan, JP-A 3-20277/1991, Banyu Pharmaceutical Co. Ltd.
Kojiri, et al., "A New Antitumor Substance BE-13793C, Produced by a Streptomycete", 44 Journal of Antibodies No. 7, Jul. 1991, pp. 723-728.
Hughes, et al., "Synthesis of the Indolo [2,3-a]carbazole Natural Products Staurosporinone and Arcyriaflavin B", J. Chemical Society Perkin Transactions, (1990), pp. 2475-2480.
Reynolds, et al., "The Preparation of .alpha.-and .beta.-Geniobiose Octaacetates", 60 Journal of the American Chemical Society, Oct. 1988, pp. 2559-2561.
Tomita, et al., J. of Antibiot., vol. 44, 1991, pp. 940-948.
Kroppenstedt, et al., In "The Prokaryotes", ed. Balows, et al., 1992, pp. 1085-1106.
Kroppenstedt et al, "The Prokaryotes", vol. II, Balows et al, ed., 1992 pp. 1085-1089.

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