Microbial process for biotransformation to (R)-3-chloro-1,2-prop

Details Microbial process for biotransformation to (R)-3-chloro-1,2-prop Microbial process for biotransformation to (R)-3-chloro-1,2-prop

1990-12-27

1998-12-08

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435157, 4352521, 435244, C12P 718

Patent

active

058467939

ABSTRACT:
A process for preparing optically active (R)-3-chloro-1,2-propanediol, which comprises subjecting (R,S)-3-chloro-1,2-propanediol to the reaction of a microorganism belonging to genus Serratia in a reaction mixture, and then collecting the residual (R)-3-chloro-1,2-propanediol. According to the process of the present invention, (R)-3-chloro-1,2-propanediol can be efficiently prepared starting from low cost (R,S)-3-chloro-1,2-propanediol.

REFERENCES:
patent: 4313008 (1982-01-01), Jones
patent: 5017484 (1991-05-01), Nakamura
Hohn-Bentz et al., Arch. Microbiol. 116, pp. 197-203, 1978
Sigma Catalog, 1987, pp. 184-185.
J. Bacteriology 140, No. 1, 182-187 (1979), C.T. Tang et al.
J. Org. Chem. 50, No. 1, 1992-1994 (1985), Chi-huey Wong et al.
J. Biol. Chem. 249, No. 10, 3132-3139 (1974), W.G. McGregor et al.
Chemistry and Industry, "Stereospecific Synthesis of R- and S-3-chloropropan-1,2-diol", Jul. 15, 1978. & JP-A-62 993 (Osaka Soda Co., Ltd. ) 31 Mar. 1987.
ATCC Catalogue of Bacteria, 1992, p. 286.

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