Microbial process for 9.alpha.-hydroxylation of steroids

Details Microbial process for 9.alpha.-hydroxylation of steroids Microbial process for 9.alpha.-hydroxylation of steroids

1981-06-12

1983-08-09

Smith, William F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a...

435253, 435872, C12P 3306

Patent

active

043979475

ABSTRACT:
Valuable 9.alpha.-hydroxy steroids are prepared via microbial enzymatic oxidation (MEO) by conventional fermentation means, without the need for a .DELTA..sup.1 dehydrogenation inhibitor, utilizing novel microorganism Nocardia canicruria ATCC 31548. Also disclosed is a novel method using any .DELTA..sup.1 dehydrogenase producing organism and a novel bio-reactor technique means for preparing said steroids.

REFERENCES:
patent: 3065146 (1962-11-01), Sih et al .
patent: 3080298 (1963-03-01), Principe et al.

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