Microbial preparation of 13.beta.-13-deoxy-22,23-dihydro avermec

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435170, 435820, 4352521, 4352535, C12P 1718, C12P 104, C12N 120

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active

052253384

ABSTRACT:
The known compound, 13.beta.-13-deoxy-22,23-dihydro-avermectin -B1a/B1b Aglycone is prepared microbiologically from cultures of the novel microorganisms (MA-6762, ATCC 55069, MA-6763 ATCC 55070) or the known microorganism Streptomyces lavendulae MA-6555 (ATCC 14159 or ATCC 55330). The compound is prepared by the biotransformation of 13-deoxy-22,23-dihydro avermectin B1a/B1b aglycone which oxidizes the 13-position and epimerizes the 13-position hydroxy group.

REFERENCES:
patent: 4587247 (1986-05-01), Linn et al.
patent: 4666937 (1987-05-01), Goegelman et al.
JACS 75 p. 5764 (1953).

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