Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2000-08-04
2011-10-11
Steele, Amber D. (Department: 1654)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C506S006000, C506S009000
Reexamination Certificate
active
08034571
ABSTRACT:
Disclosed are methods for obtaining antigens that are expressed by pathogenic microorganism during an infection process, as well as the antigens so obtained. Also disclosed are isolated polynucleotides encoding said antigens, recombinant polypeptides expressed from the isolated polypeptides, antibodies capable of forming immune complexes with the obtained antigens, and various other compositions useful in the detection, diagnosis, prevention and/or treatment of a microbial infection. The methods of the invention utilize pooled sera from patients who have partly or completely undergone infection by a microbial organism in order to obtain genes that are expressed during in vivo but not during in vitro growth of the microbial organism.
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Brady L. Jeannine
Handfield Martin
Hillman Jeffrey D.
Progulske-Fox Ann
McDonnel Boehnen Hulbert & Berghoff LLP
Oragenics, Inc.
Steele Amber D.
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