Microbial immunosoppressant agent

Details Microbial immunosoppressant agent Microbial immunosoppressant agent

1992-06-24

1993-10-12

Dess, Jose G.

Drug, bio-affecting and body treating compositions

Immune response affecting drug

514286, 435119, 546 63, A61K 3500

Patent

active

052526127

ABSTRACT:
Described is a new immunosuppressant, L-683,756, a bisdemethylated, ring rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

REFERENCES:
New York Times (Oct. 18, 1989), pA1, by L. K. Altman.
Transplantation, vol. 32, No. 5, p. 350, by P. E. Morris.
Ann. Rev. Immunol., vol. 3, p. 415, by E. M. Sherach (1985).
J. Antiobiotics, (Nov. 1988) vol. 16 p. 1600, by Hatanaka, et al.
J. Immunology, vol. 144, pp. 251-258, No. 1, (Jan. 1, 1990).

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