Microbial immunoregulant

Details Microbial immunoregulant Microbial immunoregulant

1992-07-30

1995-07-11

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424122, 435 75, 435119, 435127, 435128, 435898, 514291, 514 23, 540456, 540452, A61K 3500, A61K 31395, C07D49816, C07F 704

Patent

active

054318963

ABSTRACT:
Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

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patent: 5138052 (1992-08-01), Chen et al.
patent: 5149701 (1992-09-01), Shafiee et al.
patent: 5162334 (1992-11-01), Goulet et al.
The Merck Manual, 15th edition pp. 322-337 (1987).

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