Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1993-04-05
1994-09-06
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424451, 424459, A61K 954
Patent
active
053446577
ABSTRACT:
The microbeads are composed of a core containing the active ingredient and a microporous membrane, insoluble in aqueous medium, consisting of a film-forming polymer, a plasticizer and a filling material.
The membrane has a thickness such that diltiazem is released in vitro at an approximately constant rate for at least 6 hours after a latent period of less than one hour.
The active ingredient can be intimately mixed with the core or included in a polyvinyl pyrrolidone layer coating an inert grain.
The sustained-release microbeads are formed by application to the core of a dispersion of the constituents of the membrane in a solvent and evaporation of the solvent.
The pharmaceutical compositions consist of capsules containing the microbeads. They are administered orally one or twice per day, depending on the dose, for the treatment of angina or hypertension.
REFERENCES:
patent: 4808413 (1989-02-01), Joshi et al.
patent: 4894240 (1990-01-01), Geoghegan et al.
patent: 4917899 (1990-04-01), Geoghegan et al.
patent: 5149542 (1992-09-01), Valducci
Benston, Jr. William E.
Elf Sanofi
Page Thurman K.
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