Microarray-mediated diagnosis of herpes virus infection by...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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08071305

ABSTRACT:
The present invention discloses disease-associated molecules and assays, which are useful for diagnosing and assessing those animals with herpes virus infection, and determining those animals at risk of developing an herpes virus infection or its sequelae. The invention has practical use in the early diagnosis of disease, in monitoring an animal's immune response to the disease, and in enabling better treatment and management decisions to be made in clinically and sub-clinically affected animals.

REFERENCES:
patent: WO 2005/067649 (2005-07-01), None
Jones, J. et al., (2003) J. Virology; vol. 77 No. (2); pp. 1268-1280 “Microarray Analysis of Host Cell Gene Transcription in Response to Varicelle-Zoster Virus Infection of Human T-cells and Fibroblasts in Vitro and in SCIDhu Skin Xenografts in Vivo”.
Naranatt, P.P., et al., (2004) Cancer Research; vol. 64; pp. 72-84; “Host Gene Induction and Transcriptional Programming in Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8)-Infected Endothelial, Fibroblast and B Cells: insights into Modulation Events Early during Infection”.
Wilcox and Raidal, 2000, Role of Viruses in Respiratory Disease, RIRDC Publication No. 00/146, RIRDC Project No. UMN-22A.
M. Dunowska, et al., 2002, New Zealand Veterinary Journal vol. 50, No. 4, pp. 132-139, Viruses Associated with Outbreaks of Equine Respiratory Disease in New Zealand.
M. Dunowska, et al., 2002, New Zealand Veterinary Journal vol. 50, No. 4, pp. 140-147, “Equine Respiratory Viruses in Foals in New Zealand”.
C. Walker, et al., 1999, Veterinary Microbiology, vol. 68, pp. 3-13, “Comparison of the Pathogenesis of Acute Equine Herpesvirus 1 (EHV-1) Infection in the Horse and the Mouse Model”.
M. Espy, et al, 2000, J. Clin Microbiol,. vol. 38. No. 2, pp. 795-799, “Diagnosis of Herpes Simplex Virus Infections in the Clinical Laboratory by LightCycler PCR”.
M. Shaw, et al, 2001, Antivir Chem Chemother, vol. 12. No. 3, pp. 175-186, “Ganciclovir and Penciclovir, But Not Acyclovir, Induce Apoptosis in Herpes Simplex Virus Thymidine Kinase-Transformed Baby Hamster Kidney Cells”.

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