Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2007-07-03
2007-07-03
Shukla, Ram R. (Department: 1634)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C435S006120, C435S283100, C435S287200, C422S068100
Reexamination Certificate
active
10722290
ABSTRACT:
A novel hybridization device that improves the efficiency and consistency of microarray hybridization reactions by achieving a greater degree of internal mixing of target solution. The device provides a gasket-and-cover-type chamber wherein solution mixing is achieved by the creation of a multitude of microbubbles. One or more of the inner walls that define the chamber contain bubble-rupturing elements that extend into the chamber and terminate in sharp edges. They are typically located on opposite sides of a rectangular chamber and are pointed in a direction opposing bubble movement. Their interference with larger bubbles causes their breakup into microbubbles which travel separate and distinct paths as a result of external agitation and thereby provide improved solution mixing that results in a uniform distribution of target molecules to the probe molecules bound to the substrate. The sensitivity and consistency of the hybridization reaction is significantly increased.
REFERENCES:
patent: 4750556 (1988-06-01), del Valle P. et al.
patent: 5910288 (1999-06-01), Schembri
patent: 5922591 (1999-07-01), Anderson et al.
patent: 6186659 (2001-02-01), Schembri
patent: 6258593 (2001-07-01), Schembri et al.
patent: 6420114 (2002-07-01), Bedilion et al.
patent: 6485918 (2002-11-01), Schermer et al.
patent: 6551817 (2003-04-01), Besemer et al.
patent: 6613529 (2003-09-01), Bedilion et al.
patent: 2002/0047003 (2002-04-01), Bedingham et al.
patent: 2002/0192701 (2002-12-01), Adey
patent: 2003/0087292 (2003-05-01), Chen et al.
patent: 2003/0104494 (2003-06-01), Ravkin et al.
patent: 2003/0123322 (2003-07-01), Chung et al.
patent: 2697913 (1994-05-01), None
patent: WO99/36576 (1999-07-01), None
Aldrich Techware Catalog (Sigma-Aldrich, St. Louis, MO p. 181 (1995-1996).
Williams, P.T. et al., “Catalytic pyrolysis of tyres: influence of catalyst temperature”, Fuel, IPC Science and Technology Press, Guildford, Great Britain, vol. 81, No. 18, Dec. 2002, pp. 2425-2434, XP004380934.
Gerassi Yehudit
Hahn Soonkap
Steadman Jhobe
Tsinberg Pavel
Watanaskul Tim
Biocept, Inc.
Crow Robert T.
Fitch Even Tabin & Flannery
Shukla Ram R.
LandOfFree
Microarray hybridization device having bubble-fracturing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Microarray hybridization device having bubble-fracturing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microarray hybridization device having bubble-fracturing... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3816819