Micro-well and methods of fabricating and selectively...

Details Micro-well and methods of fabricating and selectively... Micro-well and methods of fabricating and selectively...

2007-10-09

2007-10-09

Connelly-Cushwa, Michelle (Department: 2874)

Optical waveguides

Optical fiber bundle

Fiber bundle plate

C435S288400, C435S288700

Reexamination Certificate

active

10935541

ABSTRACT:
Well plates adaptable for specimen sampling in the biological, chemical and pharmaceutical sciences are fabricated by dissolving fusedly-retained cores from the cladding material of a fused fiber plate to define a capillary plate including first and second faces and a plurality of through-voids into which fluidic samples may be deposited for analysis. Closed-bottom wells are defined by bonding one of the first and second faces to a base plate or by securing into well-sealing positions over the open ends of selected through-voids optical elements, each of which optical elements exhibits a predetermined optical property. Cladding material including reducible ions is exposed to a reduction atmosphere in order to blacken selected regions of a well plate, thereby enhancing sample analysis by reducing such disadvantageous phenomena as autofluorescence.

REFERENCES:
patent: 5351332 (1994-09-01), Cook
patent: 6210910 (2001-04-01), Walt et al.
patent: 6713309 (2004-03-01), Anderson et al.
patent: 2002/0039728 (2002-04-01), Kain et al.
patent: 2004/0129676 (2004-07-01), Tan
patent: 2005/0048571 (2005-03-01), Danielson et al.

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