Micro-sonicator for spore lysis

Chemistry: molecular biology and microbiology – Apparatus – Involving lysis of a microorganism by means other than...

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4352867, 435820, 366114, 241 2, C12M 133

Patent

active

061000841

ABSTRACT:
A micro-sonicator for spore lysis. Using micromachining technology, the micro-sonicator uses ultrasonic excitation of spores to perform spore and cell lysis. The micro-sonicator comprises a container with a cavity therein for retaining the sample in an ultrasonic transmission medium, the cavity being closed by a silicon membrane to which an electrode and piezoelectric material are attached, with the electrode and piezoelectric material being electrically connected to an AC signal generator which causes the membrane to flex and vibrate at the frequency of the applied voltage.

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patent: 4983523 (1991-01-01), Li et al.
patent: 5374522 (1994-12-01), Murphy et al.
patent: 5646039 (1997-07-01), Northrup et al.
patent: 5837303 (1998-11-01), Hayden

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