Micro-size fibrinolytic plasmin

Details Micro-size fibrinolytic plasmin Micro-size fibrinolytic plasmin

1987-08-14

1988-09-27

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 424 942, 435217, 530380, A61K 37547, A61K 3747

Patent

active

047740876

ABSTRACT:
Microplasmin and microplasminogen are plasmin and plasminogen derivatives produced by the action of plasmin non plasmin/plasminogen at high pH. The action of plasmin at this pH cleaves the heavy (A) chain of plasmin at the Arg.sub.529 - Lys.sub.503 or Lys.sub.530 -Leu.sub.531 bond and promotes disulfide bond rearrangement, producing microplasmin or microplasminogen consisting of a 30 or 31 residue C-terminal peptide derived from the A chain bound through new disulfide bonds to the intact B-chain of plasmin or plasminogen. The resulting products are significantly reduced in size and retain native activity.

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Paoni et al, Biochem Biophys Res. Comm., 65(2), 757-65, 1975.
Christensen et al, Biochem Biophys Acta, 567, 472-81, (1979).
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