Micro-RNAs that modulate smooth muscle proliferation and...

Details Micro-RNAs that modulate smooth muscle proliferation and... Micro-RNAs that modulate smooth muscle proliferation and...

2011-08-09

2011-08-09

Angell, Jon E (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S04400A

Reexamination Certificate

active

07994150

ABSTRACT:
The present invention relates to the identification of microRNAs that regulate smooth muscle cell proliferation and differentiation, including the miR-143/miR-145 cluster. Methods of treating restenosis and neointima formation by increasing expression of miR-143 and/or miR-145 are disclosed. The present invention also relates to the identification of two microRNAs, miR-486 and miR-422a, that regulate cell survival in the heart. Methods of treating or preventing cardiac hypertrophy, heart failure, or myocardial infarction by increasing expression of miR-486 and/or miR-422a in heart tissue are also disclosed.

REFERENCES:
patent: 2009/0232893 (2009-09-01), Bader et al.
patent: WO 03/029459 (2003-04-01), None
patent: WO 2009/137807 (2009-11-01), None
International Search Report and Written Opinion based on International Application PCT/US2009/034887 (Nov. 25, 2009).

Affiliated with

Also associated with

Rating

Micro-RNAs that modulate smooth muscle proliferation and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Micro-RNAs that modulate smooth muscle proliferation and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Micro-RNAs that modulate smooth muscle proliferation and... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2679192