Optics: measuring and testing – By polarized light examination – With polariscopes
Patent
1983-04-27
1985-02-12
Marcus, Michael S.
Optics: measuring and testing
By polarized light examination
With polariscopes
356410, 356411, 422 70, 436161, G01N 2121, G01N 3106
Patent
active
044987749
ABSTRACT:
A micro-polarimeter interfaced with a system for high performance liquid chromatography, for quantitatively analyzing micro and trace amounts of optically active organic molecules, particularly carbohydrates. A flow cell with a narrow bore is connected to a high performance liquid chromatography system. Thin, low birefringence cell windows cover opposite ends of the bore. A focused and polarized laser beam is directed along the longitudinal axis of the bore as an eluent containing the organic molecules is pumped through the cell. The beam is modulated by air gap Faraday rotators for phase sensitive detection to enhance the signal to noise ratio. An analyzer records the beams's direction of polarization after it passes through the cell. Calibration of the liquid chromatography system allows determination of the quantity of organic molecules present from a determination of the degree to which the polarized beam is rotated when it passes through the eluent.
REFERENCES:
patent: 3602597 (1971-08-01), Sproul
patent: 3738755 (1973-06-01), Chaney et al.
Yeung et al., A New HPLC Detector Based on Optical Activity, Pitt. Conf., Analytical Chem. and Appl. Spectroscopy, Abstract 580, 3-13-80.
Scaparo et al., Appl. Phys. Lett., 35(7), Oct. 1, 1979.
Kuo Jeng-Chung
Steenhoek Larry E.
Woodruff Steven D.
Yeung Edward E.
Iowa State University & Research Foundation, Inc.
Marcus Michael S.
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