Micro injector sample delivery system for charged molecules

Details Micro injector sample delivery system for charged molecules Micro injector sample delivery system for charged molecules

1996-08-29

1999-11-09

Warden, Robert

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

204466, 204606, 204616, G01N 2746, G01N 27447

Patent

active

059807130

ABSTRACT:
A micro injector sample delivery system for charged molecules. The injector is used for collecting and delivering controlled amounts of charged molecule samples for subsequent analysis. The injector delivery system can be scaled to large numbers (>96) for sample delivery to massively parallel high throughput analysis systems. The essence of the injector system is an electric field controllable loading tip including a section of porous material. By applying the appropriate polarity bias potential to the injector tip, charged molecules will migrate into porous material, and by reversing the polarity bias potential the molecules are ejected or forced away from the tip. The invention has application for uptake of charged biological molecules (e.g. proteins, nucleic acids, polymers, etc.) for delivery to analytical systems, and can be used in automated sample delivery systems.

REFERENCES:
patent: 4270986 (1981-06-01), Smith
patent: 4301794 (1981-11-01), Tapper
patent: 4406658 (1983-09-01), Lattin et al.
patent: 5002527 (1991-03-01), Reller et al.
patent: 5088977 (1992-02-01), Sibalis

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