Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-04-19
1995-10-03
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546140, A61K 3147, C07D40110
Patent
active
054552516
ABSTRACT:
The present invention provides new antiviral compounds, i.e., michellamines and derivatives and pharmacologically acceptable salts thereof, methods for isolating such antiviral compounds from a plant species of the genus Ancistrocladus, antiviral compositions containing such antiviral compounds, and methods of using such antiviral compounds for treating patients with viral infections. The antiviral compounds of the present invention inhibit the reproduction and cytopathicity of human acquired immunodeficiency viruses.
REFERENCES:
patent: 3751419 (1973-08-01), Ziegler
Stuart-Harris, "The Background to Chemotherapy of Virus Diseases", 1965, pp. 76-77.
Manfredi et al. J. Med. Chem, vol. 34, No. 12, 1991, pp. 3402-3405.
Ruangrungsi, et al, J. Natural Products vol. 48, No. 4, 1985, pp. 529-535.
Sandstrom, Drugs, vol. 34, 1987 pp. 373-390.
Bringmann, "The Naphthyl Isoquinoline Alkaloids," The Alkaloids, vol. 29, Brossi, ed., Academic Press, New York 141-184 (1986).
Bringmann et al., Planta Med., 58 (Suppl. 1), 703-704 (1992).
Gustafson et al., "AIDS-Antiviral Sulfolipids from Cyanobacteria (Blue-Green Algae)," J. National Cancer Institute, 81 (16) (Aug. 16, 1989).
Weislow et al., "New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity," J. National Cancer Institute, 81 (8), 577-586 (Apr. 19, 1989).
Blunt John W.
Boyd Michael R.
Bringmann Gerhard
Cardellina, II John H.
Cragg Gordon M.
Davis Zinna N.
Dentz Bernard
The United States of America as represented by the Secretary of
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